Scientific Studies Which Support Isotonix® Prenatal Multivitamin:
· Ryan-Harshman M et al. Folic acid and prevention of neural tube defects. Canadian Family Physician. 54(1):36-8, 2008.
· Czeizel A et al. Dose-dependent effect of folic acid on the prevention of orofacial clefts. Pediatrics. 104(6):e66, 1999.
· Ren A et al. Comparison of blood folate levels among pregnant Chinese women in areas with high and low prevalence of neural tube defects. Public Health Nutrition. 10(8):762-8, 2007.
· Brent R et al. Further efforts to reduce the incidence of neural tube defects. Pediatrics. 119(1):225-6, 2007.
· Lindsey L et al. Understanding optimal nutrition among women of childbearing age in the United States and Puerto Rico : employing formative research to lay the foundation for national birth defects prevention campaigns. Journal of Health Communication. 12(8):733-57, 2007.
· Scholl T et al. Folic acid: influence on the outcome of pregnancy. American Journal of Clinical Nutrition. 71(5 Supplement):1295S-1303S, 2000.
· Wald N et al. Quantifying the effect of folic acid. Lancet. 358(9298):2069-2073, 2001.
· Locksmith G et al. Preventing neural tube defects: the importance periconceptional folic acid supplements. Obstetrics and Gynecology. 321(7):1027-1034, 1998.
· Suarez L et al. Maternal serum B(12) levels and risk for neural tube defects in a Texas-Mexico border population. Annals of Epidemiology. 13(2):81-88, 2003.
· Candito M et al. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. American Journal of Medical Genetics. 146(9):1128-33, 2008.
· Boyles A et al. Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. American Journal of Medical Genetics. 146(4):440-9, 2008.
· Centers for Disease Control and Prevention (CDC). Prevalence of neural tube defects and folic acid knowledge and consumption--Puerto Rico, 1996-2006. MMWR Morbidity and Mortality Weekly Report. 57(1):10-3, 2008.
· Wilson R et al. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of Obstetrics Gynecology Canada . 29(12):1003-26, 2007.
· Gupta P et al. Multimicronutrient supplementation for undernourished pregnant women and the birth size of their offspring: a double-blind, randomized, placebo-controlled trial. Archives of Pediatric and Adolescent Medicine. 161(1):58-64, 2007.
· Scholl T et al. Vitamin E: maternal concentrations are associated with fetal growth. American Journal of Clinical Nutrition. 84(6):1442-8, 2006.
· Kaiser L et al. Position of the American Dietetic Association: nutrition and lifestyle for a healthy pregnancy outcome. Journal of the American Dietetic Association. 108(3):553-61, 2008.
· Scholl T. Maternal nutrition before and during pregnancy. Nestlé Nutrition Workshop Series Pediatrics Program. 61:79-89, 2008.
· Pathak P et al. Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana. Indian Journal of Pediatrics. 71(11):1007-14, 2004. Review.
· Castillo-Durán C et al. Zinc supplementation and growth of the fetus and low birth weight infant. Journal of Nutrition. 133(5 Suppl 1):1494S-7S, 2003. Review.
· Wynn A and Wynn M. Magnesium and other nutrient deficiencies as possible causes of hypertension and low birth weight. Nutrition and Health. 6(2):69-88, 1988. Review.
· Scholl T et al. Folic acid: influence on the outcome of pregnancy. American Journal of Clinical Nutrition. 71(5 Supplement):1295S-1303S, 2000.
· Grant W et al. Benefits and requirements of vitamin D for optimal health: a review. Alternative Medicine Review. 10(2):94-111, 2005.
· Zagré N et al. Prenatal multiple micronutrient supplementation has greater impact on birth weight than supplementation with iron and folic acid: a cluster-randomized, double-blind, controlled programmatic study in rural Niger . Food and Nutrition Bulletin. 28(3):317-27, 2007.
· Hernandez-Diaz S et al. Risk of gestational hypertension in relation to folic acid supplementation during pregnancy. American Journal of Epidemiology. 156(9):806-812, 2002.
· Wen S et al. Folic acid supplementation in early second trimester and the risk of preeclampsia. American Journal of Obstetrics and Gynecology. 198(1):45.e1-7, 2008.
· Bodnar L et al. Maternal vitamin D deficiency increases the risk of preeclampsia. Journal of Clinical Endocrinology and Metabolism. 92(9):3517-22, 2007.
· Scholl T. Maternal nutrition before and during pregnancy. Nestlé Nutrition Workshop Series Pediatrics Program. 61:79-89, 2008.
· Repke J. Calcium, magnesium, and zinc supplementation and perinatal outcome. Clinical Obstetrics and Gynecology. 34(2):262-7, 1991. Review.
· Wynn A and Wynn M. Magnesium and other nutrient deficiencies as possible causes of hypertension and low birthweight. Nutrition and Health. 6(2):69-88, 1988. Review.
· Altura B et al. Magnesium deficiency-induced spasms of umbilical vessels: relation to preeclampsia, hypertension, growth retardation. Science. 221(4608):376-8, 1983.
· Hofmeyr G et al. Calcium supplementation to prevent pre-eclampsia--a systematic review. South African Medical Journal. 93(3):224-228, 2003.
· Coetzee E et al. A randomized controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-clampsia. British Journal of Obstetrics and Gynecology. 105(3):300, 1998.
· Hypponen E. Vitamin D for the prevention of preeclampsia? A hypothesis. Nutrition Reviews. 63(7):225-232, 2005.
· Chappell L et al. Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. American Journal of Obstetrics and Gynecology. 187(3):777-784, 2002.
· Chappell L et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomized trial. Lancet. 354(9181):810-816, 1999.
· Vaidya A, et al. Effects of antenatal multiple micronutrient supplementation on childrens weight and size at 2 years of age in Nepal : follow-up of a double-blind randomized controlled trial. Lancet. 371(9611):492-9, 2008.
· Wilcox A et al. Folic acid supplements and risk of facial clefts: national population based case-control study. British Medical Journal. 334(7591):464, 2007.
· Shaw G et al. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet. 346(8972):393-6, 1995.
· Goh Y et al. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. Journal of Obstetrics and Gynecology Canada . 28(8):680-9, 2006. Review.
· Lindsey L et al. Understanding optimal nutrition among women of childbearing age in the United States and Puerto Rico : employing formative research to lay the foundation for national birth defects prevention campaigns. Journal of Health Communication. 12(8):733-57, 2007.
· Goh Y et al. Prenatal supplementation with multivitamins and the incidence of pediatric cancers: clinical and methodological considerations. Pediatrics Blood and Cancer. 50(2 Suppl):487-9; discussion 498, 2008. Review.
· Scholl T. Maternal nutrition before and during pregnancy. Nestle Nutrition Workshop Series Pediatric Program. 61:79-89, 2008.
· Czeizel A et al. Dose-dependent effect of folic acid on the prevention of orofacial clefts. Pediatrics. 104(6):e66, 1999.
· Scholl T et al. Folic acid: influence on the outcome of pregnancy. American Journal of Clinical Nutrition. 71(5 Supplement):1295S-1303S, 2000.
· Czeizel A et al. Maternal use of nutritional supplements during the first month of pregnancy and decreased risk of Down's syndrome: case-control study. Nutrition. 21(6):698-704, 2005.
· Tho
· Merialdi M et al. Adding zinc to prenatal iron and folate tablets improves fetal neurobehavioral development. American Journal of Obstetrics and Gynecology. 180(2 Partt 1):483-490, 1999.
· Merialdi M et al. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth. American Journal of Clinical Nutrition. 79(5):826-830, 2004.
· Boyles A et al. Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. American Journal of Medical Genetics. 146(4):440-9, 2008.
· Morin P et al. Multivitamin supplement for primary prevention of birth defects: application of a preventive clinical practice. Canadian Family Physician. 53(12):2142-3, 2007.
· Mock D et al. Marginal biotin deficiency during normal pregnancy. American Journal of Clinical Nutrition. 75(2):295-299, 2002.
· Scholl T et al. Folic acid: influence on the outcome of pregnancy. American Journal of Clinical Nutrition. 71(5 Supplement):1295S-1303S, 2000.
· Klenner F et al. Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. Journal of Applied Nutrition. 23(3-4), 1971.
· Grant W et al. Benefits and requirements of vitamin D for optimal health: a review. Alternative Medicine Review. 10(2):94-111, 2005.
· Hollis B. Vitamin D requirement during pregnancy and lactation. Journal of Bone and Mineral Research. 22 Suppl 2:V39-44, 2007. Review.
· Kaiser L et al. Position of the American Dietetic Association: nutrition and lifestyle for a healthy pregnancy outcome. Journal of the American Dietetic Association. 108(3):553-61, 2008.