Scientific Studies Which Support
Timeless Prescription™ Oxygen Extreme :
· Abe, K., et al. Green Tea with a High Catechin Content Suppresses Inflammatory Cytokine Expression in the Galactosamine-injured Rat Liver. Biomedical Research. 26(5): 187-192, 2005.
· Alaluf, S., et al. Dietary Carotenoids Contribute to Normal Human Skin Color and UV Photosensitivity. Journal of Nutrition. 132: 399-403, 2002.
· Atalay, M., et al. Anti-angiogenic Property of Edible Berry in a Model of Hemangioma. Federation of European Biochemical Societies
. 544: 252-257, 2003. · Bagchi, D. Anti-angiogenic, Antioxidant, and Anti-carcinogenic Properties of a Novel Anthocyanin-Rich Berry Extract Formula. Biochemistry (Moscow). 69(1): 75-80, 2004.
· Beppu, M., et al. Water-soluble Antioxidants Inhibit Macrophage Recognition of Oxidized Erythrocytes. Biological & Pharmaceutical Bulletin. 24(5): 575-578, 2001.
· Bettuzzi, S., et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-grade Prostate Intraepithelial Neoplasia: a Preliminary Report from a One-year Proof-of-Principle Study. Cancer Research. 66(2): 1234-1240, 2006.
· Chan, D., et al. Regulation of Procollagen Synthesis and Processing during Ascorbate-induced Extracellular Matrix Accumulation In Vitro. Biochemical Journal. 269: 175-181, 1990. · Chao, J. and Chu, C. Effects of Ginkgo biloba Extract on Cell Proliferation and Cytotoxicity in Human Hepatocellular Carcinoma Cells. World Journal of Gastroenterology. 10(1): 37-41, 2004.
· Chao, J., et al. Effects of Ginkgo biloba Extract on Cytoprotective Factors in Rats with Duodenal Ulcer. World Journal of Gastroenterology. 10(4): 560-566, 2004.
· Craig, W. Health-promoting Properties of Common Herbs. American Journal of Clinical Nutrition. 70(3): 491S-499S, 1999.
·
Davidson, J., et al. Ascorbate Differentially Regulates Elastin and Collagen Biosynthesis in Vascular Smooth Muscle Cells and Skin Fibroblasts by Pretranslational Mechanisms. Journal of Biological Chemistry. 272 (1): 345-352, 1997.
· Davis-Searles, P., et al. Milk thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum Marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells. Cancer Research. 65(10): 4448- 4457, 2005.
· All-trans and 9-cis Retinoic Acids, Retinol and Beta-carotene Chemopreventive Activities during the Initial Phases of Hepatocarcinogenesis Involve Distinct Actions on Glutathione S-transferase Positive Preneoplastic Lesions Remodeling and DNA Damage. Carcinogenesis. 26(11): 1940-1946, 2005.
· Dhingra, S. and Bansal, M. Hypercholesterolemia and Apolipoprotein B Expression: Regulation by Selenium Status. Lipids in Health and Disease. 4: 28, 2005.
· Ellis, G., et al.
Neutrophil Superoxide Anion–generating Capa c ity, Endothelial Fun c tion and Oxidative Stress in Chroni c Heart Failure: Effe c ts of Short- and Long-term V itamin C Therapy. Journal of the American
C ollege of
C ardiology. 36: 1474 – 1482, 2000.
· Engelhart, M.
Dietary Intake of Antioxidants and Risk of Alzheimer Disease . The Journal of the American Medical Association . 287:3223-3229, 2002.
· Garcia-Casal, M., et al. Vitamin A and Beta-carotene Can Improve Nonheme Iron Absorption from Rice, Wheat and Corn By Humans. Journal of Nutrition. 128(3): 646-650, 1998.
· Gonzalez, S., et al. Dietary Lutein/Zeaxanthin Decreases Ultraviolet B-Induced Epidermal Hyperproliferation and Acute Inflammation in Hairless Mice. Journal of Investigative Dermatology. 121: 399-405, 2003.
· Gu, M., et al. Silibinin Inhibits Ultraviolet B Radiation-induced Mitogenic and Survival Signaling, and Associated Biological Responses in SKH-1 Mouse Skin. Carcinogenesis. 26(8): 1404-1413, 2005.
· Gu, M., et al. Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, Mitogen-Activated Protein Kinases, and Akt Signaling. Cancer Research. 64: 6349-6356, 2004.
· He, S., et al. Effects of Extract from Ginkgo biloba on Carbon Tetrachloride-induced Liver Injury in Rats. World Journal of Gastroenterology. 12(24): 3924-3928, 2006.
· Head, K. Natural Therapies for Ocular Disorders, Part Two: Cataracts and Glaucoma. Alternative Medicine Review. 6(2): 141-166, 2001.
· Heinrich, U., et al.
Supplementation with {beta}-Carotene or a Similar Amount of Mixed Carotenoids Protects Humans from UV-Induced Erythema. Journal of Nutrition. 133(1): 98-101, 2003. · Hsu, S. and Dickinson, D. A New Approach to Managing Oral Manifestations of Sjogren's Syndrome and Skin Manifestations of Lupus. Korean Society for Biochemistry and Molecular Biology. 39(3): 229-239, 2006.
· Huang, H., et al.
Effe c ts of V itamin C and V itamin E on In Vivo Lipid Peroxidation: Results of a Randomized Controlled Trial. American Journal of
C lini
c al Nutrition. 76: 549 – 555, 2002.
· Huang, S., et al. Effect of Ginkgo biloba Extract on Livers in Aged Rats. World Journal of Gastroenterology. 11(1): 132-135, 2005.
· Ito, Y., et al. Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study.
Journal of Epidemiology. 16(4): 154-160, 2006.
· Jang, Y., et al. Anthocyanins Protect against A2E Photooxidation and Membrane Permeabilization in Retinal Pigment Epithelial Cells. Photochemistry and Photobiology. 81(3): 529-536, 2005.
· Jia, X. and Han, C. Chemoprevention of Tea on Colorectal Cancer Induced by Dimethylhydrazine in Wistar Rats. World Journal of Gastroenterology. 6(5): 699-703, 2000.
· Kidd, P. A Review of Nutrients and Botanicals in the Integrative Management of Cognitive Dysfunction. Alternative Medicine Review. 4(3): 144-161, 1999.
· Kim, H., et al. Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase Activities. Bioscience, Biotechnology, and Biochemistry. 68(9): 1977-1979, 2004.
· Kren, V. and Walterova, D. Silybin and Silymarin—New Effects and Applications. Biomedical Papers. 149(1): 29-41, 2005.
· Kupka, R., et al. Selenium Status is Associated with Accelerated HIV Disease Progression among HIV-1-infected Pregnant Women in Tanzania. Journal of Nutrition. 134: 2556-2560, 2004.
· Lasse, M., et al. Anthocyanins Induce Cell Cycle Perturbations and Apoptosis in Different Human Cell Lines. Carcinogenesis. 25(8): 1427-1433, 2004.
· Li, L., et al. Silibinin Prevents UV-Induced HaCaT Cell Apoptosis Partly through Inhibition of Caspase-8 Pathway. Biological & Pharmaceutical Bulletin. 29(6): 1096-1101, 2006.
· Logan, A. and Wong, C. Chronic Fatigue Syndrome: Oxidative Stress and Dietary Modifications. Alternative Medicine Review. 6(5): 450-459, 2001.
· Manna, S. Silymarin Suppresses TNF-induced Activation of NF-kappa B, c-Jun N-terminal Kinase, and Apoptosis. Journal of Immunology. 163(12): 6800-6809, 1999.
· Mantena, S., et al. Orally Administered
Green Tea Polyphenols Prevent Ultraviolet Radiation-Induced Skin Cancer in Mice through Activation of Cytotoxic T Cells and Inhibition of Angiogenesis in Tumors. Journal of Nutrition. 135: 2871-2877, 2005.
· Mayne, S. Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research. Journal of Nutrition. 133: 933S-940S, 2003.
· Mayne, S. Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research. Journal of Nutrition. 133: 933S-940S, 2003.
· McArdle, F., et al. Effects of Oral Vitamin E and ß-carotene Supplementation on Ultraviolet Radiation–induced Oxidative Stress in Human Skin. American Journal of Clinical Nutrition. 80(5): 1270-1275, 2004.
· Nakajima, J., et al. LC/PDA/ESI-MS Profiling and Radical Scavenging Activity of Anthocyanins in Various Berries. Journal of Biomedicine and Biotechnology. 2004(5): 241-247, 2004.
· Ogasawara, M., et al. Differential Effects of Antioxidants on the In Vitro Invasion, Growth and Lung Metastasis of Murine Colon Cancer Cells. Biological & Pharmaceutical Bulletin. 30(1):200-204, 2007.
· Ohta, Y., et al. Effect of Oral Vitamin E Administration on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator. Biological & Pharmaceutical Bulletin. 29 (4):675-683, 2006.
· Paleologos, M., et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.
· Park, Y., et al. Preventive Effect of Ginkgo biloba Extract (GBB) on the Lipopolysaccharide-induced Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 via Suppression of Nuclear Factor-kappaB in RAW 264.7 Cells. Biological & Pharmaceutical Bulletin. 29(5): 985-990, 2006.
· Pence, B., et al. Effects of Dietary Selenium on UVB-Induced Skin Carcinogenesis and Epidermal Antioxidant Status. Journal of Investigative Dermatology. 102: 759-761, 1994.
· Placzek, M., et al. Ultraviolet B-Induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-alpha-T ocopherol. Journal of Investigative Dermatology. 124: 304-307, 2005.
· Ravindranath, M., et al. Epicatechins Purified from Green Tea (Camellia Sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines. Evidence Based Complementary and Alternative Medicine. 3(2): 237-247, 2006.
· Ruggiero, P., et al. Red Wine and Green Tea Reduce H pylori- or VacA-induced Gastritis in a Mouse Model. World Journal of Gastroenterology. 13(3): 349-354, 2007.
· Salonen, R., et al.
Six-Year Effe c t of C ombined Vitamin C and E Supplementation on Atheros c leroti c Progression: The Antioxidant Supplementation in Atheros c lerosis Prevention (ASAP) Study. C ir
c ulation. 107: 947 – 953, 2003.
· Sato, Y., et al. The Feeding of ?-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice. Biological & Pharmaceutical Bulletin. 27(7): 978-984, 2004.
· Shen, X., et al. Effects of Dietary Supplementation with Vitamin E and Selenium on Rat Hepatic Stellate Cell Apoptosis. World Journal of Gastroenterology. 11(32): 4957-4961, 2005.
· Simon, J., et al.
Relation of Serum Ascorbic Acid to Mortality among US Adults. Journal of the American College of Nutrition. 20: 255-263, 2001.
· Singh, R., et al. Dietary feeding of Silibinin Inhibits Advance Human Prostate Carcinoma Growth in Athymic Nude Mice and Increases Plasma Insulin-like Growth Factor-binding Protein-3 Levels. Cancer Research. 62(11): 3063-3069, 2002.
· Sparrow, J., et al. A2E-epoxides Damage DNA in Retinal Pigment Epithelial Cells. Vitamin E and Other Antioxidants Inhibit A2E-epoxide Formation. Journal of Biological Chemistry. 278(20): 18207-18213, 2003.
· Trevithick-Sutton, C., et al. The Retinal Carotenoids Zeaxanthin and Lutein Scavenge Superoxide and Hydroxyl Radicals: A ChemilumInescence and ESR Study. Molecular Vision. 12: 1127-1135, 2006.
· Tyagi, A., et al. Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G2-M Arrest, and Apoptosis. Clinical Cancer Research. 8(11): 3512-3119, 2002.
· Vahlquist, A., et al. Vitamin A in Human Skin: II Concentrations of Carotene, Retinol and Dehydroretinol in Various Components of Normal Skin. Journal of Investigative Dermatology. 79: 94-97, 1982.
· van der Brandt, P., et al. Toenail Selenium Levels and the Subsequent Risk of Prostate Cancer: a Prospective Cohort Study. Cancer Epidemiology Biomarkers & Prevention. 12: 866-871, 2003.
· van Rooij, J., et al. Oral Vitamins C and E as Additional Treatment in Patients with Acute Anterior Uveitis: a Randomised Double Masked Study in 145 Patients. British Journal of Ophthalmology. 83: 1277-1282, 1999.
· Varghese, L., et al. Silibinin Efficacy against Human Hepatocellular Carcinoma. Clinical Cancer Research. 11: 8441-8448, 2005.
· Wang, Z., et al. Inhibitory Effects of Black Tea, Green Tea, Decaffeinated Black Tea, and Decaffeinated Green Tea on Ultraviolet B Light-induced Skin Carcinogenesis in 7,12-Dimethylbenz[ a ]anthracene-initiated SKH-1 Mice. Cancer Research. 54(13): 3428-3435, 1994.
· Wei, W., et al. Prospective Study of Serum Selenium Concentrations and Esophageal and Gastric Cardia Cancer, Heart Disease, Stroke, and Total Death. American Journal of Clinical Nutrition. 79(1): 80-85, 2004.
· Wertz, K., et al. -Carotene Interferes with Ultraviolet Light A-Induced Gene Expression by Multiple Pathways. Journal of Investigative Dermatology. 124: 428-434, 2005.
· Xu, A., et al. Therapeutic Mechanism of Ginkgo biloba Exocarp Polysaccharides on Gastric Cancer. World Journal of Gastroenterology. 9(11): 2424-2427, 2003.
· Yoshida, M., et al. Combined Effect of Vitamin E and Insulin on Cataracts of Diabetic Rats Fed a High Cholesterol Diet. Biological & Pharmaceutical Bulletin. 27(3): 338-344, 2004.
· You, W. Gastric Dysplasia and Gastric Cancer: Helicobacter pylori, Serum Vitamin C, and Other Risk Factors. Journal of the National Cancer Institute. 92(19): 1607-1612, 2000. · Zhang, X., et al. Effect of Tea Polyphenol on Cytokine Gene Expression in Rats with Alcoholic Liver Disease. Hepatobiliary & Pancreatic Disease International. 5(2): 268-272, 2006.
· Zhou, B., et al. Silibinin Protects Rat Cardiac Myocyte from Isoproterenol-Induced DNA Damage Independent on Regulation of Cell Cycle. Biological & Pharmaceutical Bulletin. 29(9): 1900-1905, 2006.
· Zigman, S. Effects of Green Tea Polyphenols on Lens Photooxidative Stress. Biological Bulletin. 197: 285-286, 1999.